Every study we cite

2025-2026 Gold-Standard Update (Harvard Health / NAMS / FDA-aligned): Recent data reinforces protein 1.6g+/kg + resistance training as top levers for midlife (Pontzer, Walker). FDA/HHS 2025 updates on MHT timing benefit body comp. GLP-1 synergy. Individualize with labs (ferritin, insulin, DEXA). Sources: NEJM, NAMS, 2025 reviews.

Primary sources behind our editorial. If we make a claim, you can trace it to the paper.

HRT & menopause

Writing Group for the WHI - "Risks and benefits of estrogen plus progestin" (2002) JAMA 288:321

Manson JE et al. - "Menopausal hormone therapy and health outcomes" (2013) JAMA 310:1353

NAMS - "2022 hormone therapy position statement" Menopause 29:767

Testosterone & men

Feldman HA et al. - "Massachusetts Male Aging Study" (2002) J Clin Endocrinol Metab 87:589

Watsw FCW et al. (EMAS) - "Late-onset hypogonadism" (2010) NEJM 363:123

Endocrine Society - "Testosterone therapy guideline" (2018) J Clin Endocrinol Metab 103:1715

Sleep architecture

Ohayon MM et al. - "Meta-analysis of quantitative sleep parameters" (2004) Sleep 27:1255

GLP-1 / GIP

Wilding JPH et al. - "STEP-1 semaglutide" (2021) NEJM 384:989

Jastreboff AM et al. - "SURMOUNT-1 tirzepatide" (2022) NEJM 387:205

Clinical resources

PubMed - https://pubmed.ncbi.nlm.nih.gov Free abstracts, often free full-text via PMC.

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2027 Pro Tips for This Topic

Track your progress with Oura or similar. Reassess every 90 days. Combine with resistance training and protein for best results. This is decision-grade, not fluff – use the linked tools and letter sequence.

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